Abstract

During differentiation and development, cell fate and identity are controlled by waves of genetic reprogramming that directly affect the functional organization of the cell nucleus and the RNA biogenesis pathway from the gene to polyribosomes. Actin and myosin have emerged as key regulators of gene expression by participating in chromatin organization, in different phases of gene transcription and in assembly of nascent ribonucleoprotein complexes. An exciting development is the discovery that these nuclear actin-based mechanisms are important during nuclear reprogramming. With this in mind, I will discuss recent work from my lab on how actin and myosin are believed to regulate transcription and chromatin on a global scale. I will focus on their direct involvement in genome organization and how these mechanisms may impact the acquisition of cell fate and identity.

Om Piergiorgio Percipalle

Dr. Percipalle has a degree in chemistry and a PhD in Molecular Genetics obtained from the International School for Advanced Studies, Trieste, Italy. As PhD student he trained at the International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste. For postdoctoral training he worked at the Medical Research Council Laboratory of Molecular Biology, Cambridge, UK, and at the Karolinska Institutet, Stockholm, in the Department of Cell and Molecular Biology. Dr. Percipalle joined the same Department as Group Leader and, later on, as Associate Professor of Cell Biology with grants from the Swedish Research Council and Cancer Society (Cancerfonden). His research activities focus on transcriptional and posttranscriptional control of gene expression and their impact on cell fate and identity. In 2015 he moved to New York University Abu Dhabi as Associate Professor of Biology. He currently holds an appointment as Guest Professor in the Department of Molecular Biosciences, The Wenner Gren Institute, Stockholm University where his research activities are funded by the Swedish Research Council and Cancer Society.

Kontaktinformation

Associate Professor Piergiorgio Percipalle, PhD
New York University Abu Dhabi
Saadiyat Campus
P.O. Box 129188
Abu Dhabi, United Arab Emirates
e-post: pp69@nyu.edu

Värd

Professor Ülo Langel, Institutionen för neurokemi