"GABAergic inhibition in neocortical dendrites"



Inhibitory GABAergic interneurons provide important control over the activity of neurons in the neocortex.  The vast majority of inhibitory synapses are formed in the dendrites of their target cells, where their function is not well understood.  We show that GABAergic connections exert highly compartmentalized control over dendritic calcium signals and excitatory inputs.  We also find that dendritic inhibition is uniquely sensitive to plasticity induction via the actions of NMDA-type glutamate receptors.  Together, our results illustrate a dynamic interplay of excitation and inhibition that likely contributes to the development and function of cortical circuits.



Michael J. Higley  MD, PhD
Assistant Professor of Neuroscience
Program in Cellular Neuroscience, Neurodegeneration and Repair
Yale School of Medicine
295 Congress Ave.
New Haven, CT 06536

e-post: m.higley@yale.edu