Abstract

I have previously worked on mice in three major projects on topics ranging from developmental disorder (such as genomic imprinting) to neuromodulation to specific neurodegenerative disease. Mice have proven to be good model systems being instrumental to our understanding of many human diseases including neurodegenerative diseases. In this seminar I will present excerpts from two of my previous research work. Namely-

1.      Modulation of aminergic neurons by a vesicular transporter protein.

2.      Experimental mouse models of Tauopathy

There are certain obvious constraints while using mouse to model a human disorder. For example, mice are more resilient to alterations and therefore there is no good models for many human diseases; more so for neurodegenerative disorders as they also have a short lifespan. A conscious shift towards studying human diseases using human material now has been made.

The current and future projects at Nielsen lab here at the Department of Neurochemistry will involve using human and mouse fluid and tissue samples as well as human cell lines to study and evaluate biomarkers- both classical and candidate biomarkers for neurodegenerative diseases like dementia, Tauopathy and alpha-synucleinopathy.  

Kontaktinformation

Dr. Kalicharan Patra, Institutionen för neurokemi

e-post: kalicharan.patra@neurochem.su.se